International Journal of Science , Engineering and Management (IJSEM)

Monthly Journal for Science , Engineering and Management

Volume2,August 2017,

Topic : Electro spun PLGA-PVA nano fibrous scaffolds: promising carriers for Curcumin

Authors:P.Jhansi Lakshmi, || S.Sundar Manoharan, Pravin walke

Abstract:Curcumin is a naturally occurring gist with innate antimicrobial and wound healing properties. Owing to its manifold mechanism of actions, curcumin is apt at the present time existing antibiotics to first-rate for unwilling bacteria. Curcumin’s pitiable aqueous solubility and speedy degradation contour hinder its usage; nano enabled drug delivery system over comes this snare and facilitates unmitigated topical deliverance of Curcumin. The current cram is paying attention on the development of PLGA-PVA nano fibers loaded with Curcumin (Cur) by electro spinning technique. PLGA and PVA were blended in the ratios of 75:25, 65:35 and 50:50 correspondingly, for the fabrication of scaffold. Curcumin was weighed down with the sample containing equal amounts of PLGA and PVA. Process optimization was carried out by standardizing the Viscosity, Molecular weight of the polymer, Voltage, temperature, tip-collector distance, Solution flow rate for fiber formation. The alteration in fiber dimension and morphology of the electro spun nano fibers was obtained by field emission scanning electron microscopy (FESEM). In vitro release properties of the prepared scaffolds were observed by simulated fluid conditions of pH 7.4, 37°C incubation in rotary shaker incubator. The release profile from the drug loaded fibers showed varied release profiles with respect to their Lactidyl:Glycodyl ratio variations, which confirms the dissolution of the drug in the polymer fractions. On the whole, we hypothesize the suitable carrier material for Curcumin.

Keywords: PLGA, Curcumin, PVA, Electro spinning, nano carrier, In vitro degradation, Bio availability, nano fibers , biodegradable, wound healing.

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DOI: 01.1617/vol4/iss8/pid87315

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Dr.Muhammad Ishtiaq,
Mirpur University of
Science & Technology,
Mirpur, Azad Kasmir.

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ISSN(Online): 2456-1304

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Thomson Reuters ID : q-6288-2016.
ORCiD Research ID : 0000-0001-9540-6799

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Journal Code : IJSEM
Electronic ISSN : 2456-1304
Impact Factor : 2.7
Frequency : Monthly
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