International Journal of Science , Engineering and Management (IJSEM)

Monthly Journal for Science , Engineering and Management

Volume2,August 2017,

Topic : Synthesis, Characterization, Industrial Application and Anticancer Activity of New N-Mustard Substituted Coumarin Derivatives

Authors:A Barasara || M Pandya, D Purohit

Abstract:A series of N-mustard Substituted-coumarin have been synthesized characterized and evaluated for their in vitro cytotoxicity and anticancer activity against PC-3 human cancer cell lines. The methodology involves nucleophilic substitution of readily accessible 3-Cyano-4-chloro coumarin with ethanol amine further on chlorination gives substituted 4-(bis(2- chloroethyl)amino)-2-oxo-2H-chromene-3-carbonitrile derivatives. Among these compounds screened, three compounds (ASW-2g, ASW-2f and ASW-2e) showed GI50 range from 80 to 95 μg/ml. All synthesized compounds were characterized by IR, NMR and Mass spectral analysis and screened for anticancer activity using PC-3 cell line. All the compounds showed moderate to good anticancer activity..

Keywords: 4-chloro-3-cyano coumarin, Aniline mustard, Anticancer activity, Nucleophilic substitution, Spectral analysis

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DOI: 01.1617/vol4/iss8/pid50483


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Dr.Muhammad Ishtiaq,
Mirpur University of
Science & Technology,
Mirpur, Azad Kasmir.

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IMPACT FACTOR: 2.7

ISSN(Online): 2456-1304

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Thomson Reuters ID : q-6288-2016.
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Journal Code : IJSEM
Electronic ISSN : 2456-1304
Impact Factor : 2.7
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