Volume2 ,August 2017.
Topic : Synthesis, Characterization, Industrial Application and Anticancer Activity of New N-Mustard Substituted Coumarin Derivatives
Authors:A Barasara || M Pandya, D Purohit
Abstract:A series of N-mustard Substituted-coumarin have been synthesized characterized and evaluated for their in vitro cytotoxicity and anticancer activity against PC-3 human cancer cell lines. The methodology involves nucleophilic substitution of readily accessible 3-Cyano-4-chloro coumarin with ethanol amine further on chlorination gives substituted 4-(bis(2- chloroethyl)amino)-2-oxo-2H-chromene-3-carbonitrile derivatives. Among these compounds screened, three compounds (ASW-2g, ASW-2f and ASW-2e) showed GI50 range from 80 to 95 μg/ml. All synthesized compounds were characterized by IR, NMR and Mass spectral analysis and screened for anticancer activity using PC-3 cell line. All the compounds showed moderate to good anticancer activity..
Keywords: 4-chloro-3-cyano coumarin, Aniline mustard, Anticancer activity, Nucleophilic substitution, Spectral analysis