Author : Ramakrishna Vasireddi 1
Date of Publication :23rd September 2016
Abstract: The synthesis of γ-Fe2O3 nanoparticles of varying particle size has been achieved using different molar concentrations of sodium hexametaphosphate while the effect of changing pH has been studied. Iron chloride, sodium hexametaphosphate and sodium hydroxide are used as precursor, reducing agent and accelerator respectively. The synthesized γ-Fe2O3 nanoparticles have been characterized by FESEM study, X-ray diffractometry, Raman spectroscopy and UV-vis spectroscopy. The nanoparticle size and morphology are determined by FESEM. From XRD analysis, γ-Fe2O3 nanoparticles were found to exhibit tetragonal structure as confirmed from well defined diffraction peaks. The visible photoluminescence (PL) emission from the synthesized γ- Fe2O3 nanocrystals has been recorded and peak values are occurred at 370 nm, 371 nm and 373 nm for the pH of 5, 7 and 9 respectively. In case of UV-vis spectra, band gap was estimated and the particle size increased with the increase of the pH values. The synthesized γ-Fe2O3 nanoparticles may be extremely useful in biomedical, drug delivery applications
Reference :
-
- A. Ito, M. Shinkai, H. Honda, T. Kobayashi, “Medical application of functionalized magnetic nanoparticles,” Journal of Biosci Bioeng. 100(1), 1-11, 2005
- Q. A. Pankhurst, J. Connolly, S. K. Jones, J. Dobson, “Applications of magnetic nanoparticles in biomedicine,” Journal of Phys D Appl Phys, 36(13), R167- 81, 2003.
- R.S. Molday, L. L. Molday, “Separation of cells labeled with immunospecific iron dextran microspheres using high-gradient magneticchromatography,” Journal of FEBS Lett, 170(2), 232-8, 1984.
- J.K. Vasir, V. Labhasetwar, “Targeted drug delivery in cancer therapy,” Journal of Technol Cancer ResT, 4(4), 363-74, 2005.
- F. Scherer, M. Anton, U. Schillinger, J. Henke, C. Bergemann, A. Kruger, B, Gänsbacher, C, Plank, “Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo,” Gene Their, 9(2), 102-9, 2002
- A. Radbruch, B. Mechtold, A. Thiel, S. Miltenyi, E. Pfluger, “Highgradient magnetic cell sorting,” Journal of Method Cell Biol., 42, 387-403, 1994.
- A. Jordan, R. Scholz, P. Wust, H. Schirra, T Schiestel, H. Schmidt, r. Felix, “Endocytosis of dextran and silan-coated magnetite nanoparticles and the effect of intracellular hyperthermia on human mammary carcinoma cells in vitro,” Journal of Magn Mater., 194, 185-96, 1999.
- P. Moroz, S.K. Jones, B.N. Gray, “Magnetically mediated hyperthermia: current status and future directions,” Journal of Hyperther., 18(4), 267-84, 2002.
- M.F. Kircher, J.R. Allport, M.Zhao, L. Josephson, A.H. Lichtman, R. Weissleder, “Intracellular magnetic labeling with CLIO-Tat for efficient in vivo tracking of cytotoxic T cells by MR imaging,” Journal of Radiology, 225, 453, 2002.
- M. Lewin, N. Carlesso, C. H. Tung, X.W. Tang, D. Cory, D.T. Scadden, R. Weissleder, “Tat peptidederivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells,” Journal of Nat Biotechnol., 18(4), 410-4, 2000.