Open Access Journal

ISSN : 2456-1304 (Online)

International Journal of Engineering Research in Electronics and Communication Engineering(IJERECE)

Monthly Journal for Electronics and Communication Engineering

Open Access Journal

International Journal of Science Engineering and Management (IJSEM)

Monthly Journal for Science Engineering and Management

ISSN : 2456-1304 (Online)

Electro spun PLGA-PVA nano fibrous scaffolds: promising carriers for Curcumin

Author : P.Jhansi Lakshmi 1 S.Sundar Manoharan 2 Pravin walke 3

Date of Publication :17th August 2017

Abstract: Curcumin is a naturally occurring gist with innate antimicrobial and wound healing properties. Owing to its manifold mechanism of actions, curcumin is apt at the present time existing antibiotics to first-rate for unwilling bacteria. Curcumin’s pitiable aqueous solubility and speedy degradation contour hinder its usage; nano enabled drug delivery system over comes this snare and facilitates unmitigated topical deliverance of Curcumin. The current cram is paying attention on the development of PLGA-PVA nano fibers loaded with Curcumin (Cur) by electro spinning technique. PLGA and PVA were blended in the ratios of 75:25, 65:35 and 50:50 correspondingly, for the fabrication of scaffold. Curcumin was weighed down with the sample containing equal amounts of PLGA and PVA. Process optimization was carried out by standardizing the Viscosity, Molecular weight of the polymer, Voltage, temperature, tip-collector distance, Solution flow rate for fiber formation. The alteration in fiber dimension and morphology of the electro spun nano fibers was obtained by field emission scanning electron microscopy (FESEM). In vitro release properties of the prepared scaffolds were observed by simulated fluid conditions of pH 7.4, 37°C incubation in rotary shaker incubator. The release profile from the drug loaded fibers showed varied release profiles with respect to their Lactidyl:Glycodyl ratio variations, which confirms the dissolution of the drug in the polymer fractions. On the whole, we hypothesize the suitable carrier material for Curcumin

Reference :

    1. Anand P, Sundaram C, Jhurani S, Kunnumakkara AB, Aggarwal BB. Curcumin and cancer: an “old-age” disease with an “ageold” solution. Cancer Lett 2008; 267(1):133-64.
    2. Gunes H, Gulen D, Mutlu R, Gumus A, Tas T, Eren Topkaya A. Antibacterial effects of curcumin: an in vitro minimum inhibitory concentration study. Toxicol Ind Health 2013.
    3. Sandur SK, Ichikawa H, Pandey MK, Kunnumakkara AB, Sung B, Sethi G, et al. Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane). Free Radic Biol Med 2007;43(4):568-80)
    4. Somparn P, Phisalaphong C, Nakornchai S, Unchern S, Morales NP. Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives. Biol Pharm Bull 2007;30(1):74-8.
    5. Kulac M, Aktas C, Tulubas F, Uygur R, Kanter M, Erboga M, et al. The effects of topical treatment with curcumin on burn wound healing in rats. J Mol Histol 2013;44(1):83-90
    6. Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J 2013;15(1):195- 218
    7. Flora G, Gupta D, Tiwari A. Nano curcumin: a promising therapeutic advancement over native curcumin. Crit Rev Ther Drug Carrier Syst 2013;30(4):331-68.
    8. Chereddy KK, Coco R, Memvanga PB, Ucakar B, des Rieux A, Vandermeulen G, et al. Combined effect of PLGA and curcumin on wound healing activity. J Control Release 2013;171(2):208-15.

Recent Article