Date of Publication :16th September 2017

Abstract: The greater wax moth Galleria mellonella attracts the view of many researchers by their anatomical, functional and molecular profiling patterns. Mostly the larvae feeds on honey bee hive and Larvae of the greater wax moth Galleria mellonella have been shown to provide a useful insight into the pathogenesis model of a wide range of microbial infections including mammalian fungal (Fusarium oxysporum, Aspergillus fumigatus, Candida albicans) and bacterial pathogens, such as Staphylococcus aureus, Proteus vulgaris, Serratia marcescens, Pseudomonas aeruginosa, Listeria monocytogenes or Enterococcus faecalis [1]. Like mammals, insects possess a complex innate immune system. In addition, analogies are found between the epithelial cells of insect larval midguts and intestinal cells of mammalian digestive systems. Finally, several basic components essential for the bacterial infection process such as cell adhesion, resistance to antimicrobial peptides, tissue degradation and adaptation to oxidative stress are likely to be important in both insects and mammals [2]. Thus, insects are polyvalent tools for the identification and characterization of microbial virulence factors involved in mammalian infections [1]. In 1934, many researchers focused on studying the larval body fluids to understand the biochemical mechanism of the honey bee moth. The larva of Galleria mellonella is available as in commercial for feeding the predatory insects. Not only this organism is used an innate immunity model but also it is now investigating for doing a research in genetic hereditary studies of sterility mechanism. The main aim of this review paper is to provide the current knowledge of this organism anatomical, functional, molecular profiling. My future aspects is to do whole genome sequence of this organism and also to create novel knock out model for understanding the interaction of foreign particles with the innate immune response disorders

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