International Journal of Engineering Research in Electronics and Communication Engineering

Effect of Marine Lipids on Innate Immunity, Represented by NK Cell Activity

Author : H. Al-Khalaifah ¹

Date of Publication :11th April 2018

Abstract: The objective of the current experiment was to study the effect of long chain omega-3 polyunsaturated fatty acids (PUFA), present in marine algae, on an innate immune response, represented by NK cell activity. One day old Cobb 500 broiler chickens (n=17) were fed on DHA algal biomass-enriched diet until 35 d of age. At slaughter, samples of blood were collected. Natural killer (NK) cell activity was analyzed. It was higher in blood samples of birds fed algal biomass than the control group. This suggests that algal biomass-rich diet may be used to enhance the innate immunity, represented by the NK cell activity.

Reference :

1. Meydani, S.H., et al., Fish Oil and Tocopherol-Induced Changes in NaturalKiller Cell-Mediated Cytotoxicity and PGE2 Synthesis in Young and Old Mice. The journal of nutrition, 1988. 118: p. 1245-1225.
2. Fritsche, K.L. and P.V. Johnston, Modulation of eicosanoid production and cell-mediated cytotoxicity by dietary α-linolenic acid in BALB/c mice. Lipids 1989 24(4): p. 305-311
3. Yaqoob, P., E.A. Newsholme, and P.C. Calder, Inhibition of natural killer cell activity by dietary lipids. Immunology Letters, 1994. 41: p. 241-247.
4. Jeffery, N.M., E.A. Newsholme, and P.C. Calder, The level of polyunsaturated fatty acids and the n-6 to n-3 polyunsaturated fatty acid ratio in the rat diet both affect serum lipid levels and lymphocyte functions. Prostaglandins, Leukotrienes and Essential Fatty Acids, 1997. 57: p. 149- 160.
5. Almallah, Y.Z., et al., Distal procto-colitis, natural cytotoxicity, and essential fatty acids. The American Journal of Gastroenterology, 1998. 93(5): p. 804-809.
6. Almallah, et al., Distal procto-colitis and n-3 polyunsaturated fatty acids: the mechanism(s) of natural cytotoxicity inhibition. European Journal of Clinical Investigation, 2000. 30(1): p. 58-65.
7. Peterson, L., et al., Eicosapentaenoic and docosahexaenoic acids alter rat spleen leukocyte fatty acid composition and prostaglandin E2 production but have different effects on lymphocyte functions and cell-mediated immunity. Lipids, 1998. 33(2): p. 171-180.
8. Thies, F., et al., Dietary supplementation with γ-linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans. Journal of Nutritional and Environmental Medicine, 2001. 131(7): p. 1918-1927.
9. Rymer, C., R.A. Gibbs, and D.I. Givens, Comparison of algal and fish sources on the oxidative stability of poultry meat and its enrichment with omega-3 polyunsaturated fatty acids. Poult Sci, 2010. 89(1): p. 150-159.
10. Abril, J.R. and W.R. Barclay, Production of docosahexaenoic enriched poultry eggs and meat using an algae based feed ingredient.The Return of w3 Fatty Acids into the Food Supply. I. Land-Based Animal Food Products and Their Health Effects., in World Review of Nutrition and Dietetics, A.P. Simopoulos, Editor. 1998: Basel, Karger. p. 77-88.