International Journal of Engineering Research in Electronics and Communication Engineering

One Dimensional Study of Calcium Distribution in a Hepatocyte cell in presence of Buffer by Finite Volume Model

Author : Yogita Jagtap ¹ Neeru Adlakha ²

Date of Publication :20th April 2018

Abstract: Calcium is ubiquitous second messenger which controls vital functions of almost all eukaryotic cells. Hepatocyte cell is parenchymal cell of liver. The regulation of calcium concentration in a hepatocyte cell is still not well understood. A model is proposed in this paper to study the distribution of calcium concentration in a hepatocyte cell in presence of buffers. The parameters like concentration of buffer, diffusion coefficient of calcium etc. have been incorporated in the model in the form of boundary value problem in one dimension. The boundary conditions have been formed to incorporate bio physiological facts of the problem. The finite volume method has been implemented to obtain the solutions. The program is developed on MATLAB 2014a to obtain numerical results and they are used to study the effect of buffers on calcium concentration in hepatocyte cell in steady state case. The information can be generated by developing such models of calcium concentration in hepatocyte cell for proper health care of liver.

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