Date of Publication :14th November 2018

Abstract: Depression is a medical illness that negatively effects how you feel and actually how u act. It is a psychotic disorder. According to most widely accepted Monoamine hypothesis, there is deficiency of catecholamine in brain (neuronal junction). When in excess, causes hyper manic condition, anti-depressant actually acts by inhibiting the re- uptake of serotonin, non-epinephrine and to a lesser extent dopamine so as increasing the concentration of catecholamine between the neuronal functions, but we know the side effects of anti-depressants such as nausea, increased appetite, weight gain, erectile dysfunctions, fatigue and drowsiness, insomnia, dry mouth at sometimes even not effective in major depression. So the solutions for these problems in rTMS (Reverse Trans cranial Magnetic Stimulation). TMS is generally used when other treatments fail. In this technique, an electromagnetic coil efficiently delivers magnetic pulse especially to nerve cells of our prefrontal cortex and it activates decreased activity of brain in patients of depression

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