Author : Kavitha Varak 1
Date of Publication :24th October 2019
Abstract: Nanoparticles (NPs) are advantageous in treating bacterial infections. Scientists found that Selenium Nanoparticles (SeNPs), owing to their unique structure and properties, may be more effective than antibiotics as they have a larger surface area and therefore can be more in contact with the external environment. The antibacterial effect of selenium may be due to the fact that at a particular concentration nano-selenium interacts with the bacterial cell surface and penetrates into the cell, thus causing damage. Some studies in recent years have suggested the use of combination of antibiotics+SeNPs, the synergistic effect of which often surpasses their individual’s inhibitory activity. In our work we performed synergetic effect of SeNPs and 3 commercial antibiotics. We found that the Nanoparticles enhanced the reaction rates of antibiotics in a synergistic mode as well as in its own way on different kinds of pathogens
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- Knetsch MLW, Koole LH. New strategies in the development of antimicrobial coatings: the example of increasing usage of silver and silver nanoparticles. Polymers Basel.(2011);3:340–366.
- Linlin Wang, Chen Hu, Longquan Shao. The antimicrobial activity of nanoparticles: present situation and prospects for the future. International Journal of Nanomedicine (2017):12 1227-1249.
- Dizaj SM, Lotfipour F, Barzegar-Jalali M, Zarrintan MH, Adibkia K. Antimicrobial activity of the metals and metal oxide nanoparticles. Mater Sci Eng C Mater Biol Appl. (2014);44:278–284.
- Zhang L, Pornpattananangku D, Hu CM, Huang CM. Development of nanoparticles for antimicrobial drug delivery. Curr Med Chem. (2010);17(6):585–594.
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- Pelgrift RY, Friedman AJ. Nanotechnology as a therapeutic tool to combat microbial resistance. Adv Drug Deliv Rev. (2013);65(13–14):1803–1815.
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