Open Access Journal

ISSN : 2456-1304 (Online)

International Journal of Engineering Research in Electronics and Communication Engineering(IJERECE)

Monthly Journal for Electronics and Communication Engineering

Open Access Journal

International Journal of Science Engineering and Management (IJSEM)

Monthly Journal for Science Engineering and Management
Call For Paper : Vol 11, Issue 03, March 2024

ISSN : 2456-1304 (Online)

Call for Paper

Vol 11, Issue 03, March 2024

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Synergistic Effect of Selenium Nanoparticles (SeNPs) With Various Antibiotics as an Antimicrobial Activity

Author : Kavitha Varak 1 Puppala Kavya Priya 2

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Date of Publication :24th October 2019

Abstract: Nanoparticles (NPs) are advantageous in treating bacterial infections. Scientists found that Selenium Nanoparticles (SeNPs), owing to their unique structure and properties, may be more effective than antibiotics as they have a larger surface area and therefore can be more in contact with the external environment. The antibacterial effect of selenium may be due to the fact that at a particular concentration nano-selenium interacts with the bacterial cell surface and penetrates into the cell, thus causing damage. Some studies in recent years have suggested the use of combination of antibiotics+SeNPs, the synergistic effect of which often surpasses their individual’s inhibitory activity. In our work we performed synergetic effect of SeNPs and 3 commercial antibiotics. We found that the Nanoparticles enhanced the reaction rates of antibiotics in a synergistic mode as well as in its own way on different kinds of pathogens

Reference :

    1. Beyth N, Houri-Haddad Y, Domb A, Khan W, Hazan R. Alternative antimicrobial approach: nanoantimicrobial materials. Evid Based Complement Alternat Med. (2015); 2015:246012.
    2. Gupta A, Landis RF, Rotello VM. Nanoparticle-based antimicrobials: surface functionality is critical. F1000Res. (2016);5 F1000 Faculty Rev-364.
    3. Knetsch MLW, Koole LH. New strategies in the development of antimicrobial coatings: the example of increasing usage of silver and silver nanoparticles. Polymers Basel.(2011);3:340–366.
    4. Linlin Wang, Chen Hu, Longquan Shao. The antimicrobial activity of nanoparticles: present situation and prospects for the future. International Journal of Nanomedicine (2017):12 1227-1249.
    5.  Dizaj SM, Lotfipour F, Barzegar-Jalali M, Zarrintan MH, Adibkia K. Antimicrobial activity of the metals and metal oxide nanoparticles. Mater Sci Eng C Mater Biol Appl. (2014);44:278–284.
    6.  Zhang L, Pornpattananangku D, Hu CM, Huang CM. Development of nanoparticles for antimicrobial drug delivery. Curr Med Chem. (2010);17(6):585–594
    7. Ranghar S. Nanoparticle-based drug delivery systems: promising approaches against infections. Braz Arch Biol Techn. (2012);57:209–222
    8. Pelgrift RY, Friedman AJ. Nanotechnology as a therapeutic tool to combat microbial resistance. Adv Drug Deliv Rev. (2013);65(13–14):1803–1815.
    9. Wang, Q. and T.J. Webster, Nanostructured selenium for preventing biofilm formation on polycarbonate medical devices. Journal of Biomedical Materials Research Part A, (2012). 100A(12): p. 3205-3210
    10. Rayman MP. Selenium in cancer prevention: a review of the evidence and mechanism of action. Proc Nutr Soc. (2005);64(4):527–542.

    1. Beyth N, Houri-Haddad Y, Domb A, Khan W, Hazan R. Alternative antimicrobial approach: nanoantimicrobial materials. Evid Based Complement Alternat Med. (2015); 2015:246012.
    2. Gupta A, Landis RF, Rotello VM. Nanoparticle-based antimicrobials: surface functionality is critical. F1000Res. (2016);5 F1000 Faculty Rev-364.
    3. Knetsch MLW, Koole LH. New strategies in the development of antimicrobial coatings: the example of increasing usage of silver and silver nanoparticles. Polymers Basel.(2011);3:340–366.
    4. Linlin Wang, Chen Hu, Longquan Shao. The antimicrobial activity of nanoparticles: present situation and prospects for the future. International Journal of Nanomedicine (2017):12 1227-1249.
    5. Dizaj SM, Lotfipour F, Barzegar-Jalali M, Zarrintan MH, Adibkia K. Antimicrobial activity of the metals and metal oxide nanoparticles. Mater Sci Eng C Mater Biol Appl. (2014);44:278–284.
    6. Zhang L, Pornpattananangku D, Hu CM, Huang CM. Development of nanoparticles for antimicrobial drug delivery. Curr Med Chem. (2010);17(6):585–594.
    7. Ranghar S. Nanoparticle-based drug delivery systems: promising approaches against infections. Braz Arch Biol Techn. (2012);57:209–222
    8. Pelgrift RY, Friedman AJ. Nanotechnology as a therapeutic tool to combat microbial resistance. Adv Drug Deliv Rev. (2013);65(13–14):1803–1815.
    9. Wang, Q. and T.J. Webster, Nanostructured selenium for preventing biofilm formation on polycarbonate medical devices. Journal of Biomedical Materials Research Part A, (2012). 100A(12): p. 3205-3210
    10.  Rayman MP. Selenium in cancer prevention: a review of the evidence and mechanism of action. Proc Nutr Soc. (2005);64(4):527–542.

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